The Korean skin booster market features multiple polynucleotide and hybrid injectable products targeting skin quality improvement — Rejuran (PDRN), Juvelook (HA + PDLA), Filorga NCTF "Chanel injection," and emerging brands. Each addresses skin quality differently. This guide compares the major options.
What polynucleotide skin boosters are
- Injectable products improving skin quality.
- Different from hyaluronic acid fillers (volume).
- Stimulate collagen and elastin production.
- Repeat session series typical.
- Maintenance treatments.
Major Korean brand comparison
| Brand | Active Ingredient | Mechanism | Best For |
|---|---|---|---|
| Rejuran (PN Healer) | Polynucleotides (salmon DNA) | Tissue regeneration, skin barrier | Skin quality, fine lines |
| Rejuran HB | PDRN + HA | Hydration + regeneration | Hydration + repair |
| Juvelook | HA + Poly D-Lactic Acid (PDLA) | Volume + biostimulation | Volume + collagen |
| Filorga NCTF 135HA | HA + 53 nutrients | Nutrient delivery + hydration | Glow, radiance |
| Restylane Skinboosters | Stabilized HA | Hydration | Hydration |
| Profhilo | Hybrid HA | Bio-remodeling | Skin laxity |
Rejuran (PDRN/PN Healer)
What it is
- Polynucleotides extracted from salmon DNA.
- "Salmon sperm facial" colloquially.
- PDRN = polydeoxyribonucleotides.
- Korean original brand (PharmaResearch).
- Most viral on social media.
How it works
- Tissue regeneration support.
- Skin barrier repair.
- Anti-inflammatory effects.
- Collagen synthesis stimulation.
- Fibroblast activation.
Best for
- Skin quality improvement.
- Fine lines/texture.
- Acne scarring (Rejuran S).
- Damaged barrier.
- Sensitive skin.
Treatment protocol
- 3-4 sessions, 2-4 week intervals.
- Maintenance every 6-12 months.
- Per session: ₩150,000-₩500,000.
- Microdroplet injection technique.
Juvelook
What it is
- Hyaluronic acid + Poly D-Lactic Acid (PDLA).
- Korean innovation hybrid injectable.
- Combines volume + biostimulation.
- Newer market entry.
- Growing popularity.
How it works
- Immediate HA hydration.
- PDLA stimulates collagen.
- Long-term biostimulation.
- Biodegradable.
- Dual mechanism.
Best for
- Volume + skin quality combined.
- Skin laxity.
- Texture improvement.
- Mid-aged patients.
- Those wanting both effects.
Treatment protocol
- 2-3 sessions, 4-6 week intervals.
- Per session: ₩300,000-₩600,000.
- Longer-lasting effects than HA alone.
Filorga NCTF 135HA ("Chanel Injection")
What it is
- HA + cocktail of 53 nutrients.
- French brand popular in Korea.
- "Chanel injection" colloquial nickname (no Chanel association).
- Mesotherapy-style injection.
How it works
- Nutrient delivery to skin.
- Vitamins, amino acids, minerals.
- HA hydration component.
- Glow and radiance focus.
Best for
- Glow and radiance.
- Dull skin.
- Photoaging.
- Hydration.
- Maintenance treatments.
Treatment protocol
- 3-4 sessions, 2-4 week intervals.
- Maintenance every 4-6 months.
- Per session: ₩200,000-₩500,000.
Profhilo
What it is
- Hybrid HA (high + low molecular weight).
- Italian brand.
- Bio-remodeling category.
- 5-point injection technique.
How it works
- Tissue remodeling.
- Bio-stimulation.
- Hydration.
- Skin firming.
Best for
- Skin laxity.
- Aging skin.
- Lower face especially.
- Conservative results.
Treatment protocol
- 2 sessions, 4 weeks apart.
- Maintenance every 6 months.
- Per session: ₩400,000-₩700,000.
Choosing the right brand
By concern
- Skin quality/regeneration: Rejuran.
- Volume + collagen: Juvelook.
- Glow/radiance: Filorga NCTF.
- Skin laxity: Profhilo.
- Hydration: Restylane Skinboosters.
By age demographic
- 20s-30s: Rejuran, Filorga NCTF (preventive).
- 30s-40s: Juvelook, combination.
- 40s-50s: Profhilo, Juvelook, comprehensive.
- 50s+: Combination approach.
By budget
- Entry-level: Rejuran or Filorga NCTF.
- Mid-range: Juvelook.
- Premium: Profhilo or combinations.
- Comprehensive: Multi-brand cocktails.
2026 trend: Combination treatments
Cocktail approach
- Combining different brands.
- Comprehensive skin quality.
- Korean specialty approach.
- Personalized formulations.
Hybrid injectables
- Volume + biostimulation combined.
- Newer product class.
- Emerging brands.
- Korean innovation focus.
Realistic expectations
- Skin quality improvement, not dramatic transformation.
- Series of treatments required.
- Maintenance ongoing.
- Individual response variable.
- Combined with skincare regimen.
Risks and considerations
- Bruising and swelling temporary.
- Tenderness at injection sites.
- Injection technique variation.
- Allergic reactions rare.
- Need for repeat treatments.
For international patients
- Korean originals at Korean prices.
- Substantial cost savings.
- Authentic products in Korea.
- Combined with travel.
- Maintenance challenges abroad.
Counterfeit concerns
- Korean originals authentic in Korea.
- Online purchases risky.
- Provider verification important.
- Brand authenticity check.
- Stick to licensed providers.
The honest framing
Korean polynucleotide skin booster market offers comprehensive options for skin quality improvement — each brand has specific strengths and ideal candidates. The patients who do well work with experienced providers who personalize brand selection to specific concerns, accept that skin boosters require series and maintenance, and combine injection treatments with comprehensive skincare. The patients who pursue single trendy brands without personalization or who expect dramatic transformation often face disappointment. Korean specialty clinics offer this comprehensive market with refined technique; brand selection should match concerns, not just popularity.